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Extra info for A H Grebe HS-4 Receiver
Thus, the transfer of TCRα chains resulted in the recreation of the TCRs from TR or CD25– CD4+ T cells and allowed for the meaningful comparison of TCR speciﬁcities between the subsets as the intrinsic proliferative capacity and signaling properties of the recipient cells are held constant. The extent and rate of expansion of TR and CD25– TCR-transduced T cells adoptively transferred into lymphopenic hosts were used as the most sensitive in vivo readout for the reactivity of TCRs for selfpeptide:MHC class II complexes.
25 2 The Antigen Speciﬁcity of Naturally Arising TR . . . . . . . . . 26 3 Antigenic Speciﬁcity of Induced Regulatory T Cells . . . . . . . . 28 4 The Paradox of Foreign Antigen Recognition by Regulatory T Cells . . 30 5 TR Appear to Have a Diverse TCR Repertoire That Is Different from the CD25– TCR Repertoire . . . . . . . . . 33 6 A Large Proportion of Peripheral CD25+ TCRs Have Greater Self-Reactivity than CD25– TCRs . . . . . . . . . . 34 7 What Is the Tissue Distribution of TR Target Self-Antigens?
1995). Thus, the development of autoreactive cells relative to TR is favored under the conditions of early thymectomy, and these observations suggested that the cause of autoimmunity in day 3-thymectomized mice was the insufﬁcient export of TR from the thymus during the ﬁrst few days ex utero. Further work directly demonstrated that regulatory T cells are indeed generated in the thymus, and that these thymic CD25+ CD4+ mature cells are capable of suppressor function as revealed by adoptive transfer experiments (Itoh et al.
A H Grebe HS-4 Receiver